Maternal serum triglyceride at midpregnancy and newborn weight in nondiabetic and normal BMI women
Aim: To determine whether elevated midpregnancy (24 -28 Gestational weeks) maternal serum lipid levels predict the risk of macrosomia in non-diabetic women.
Methods: Nondiabetic pregnant women (who had negative diabetic screens) were enrolled. Fasting serum triglyceride, and total cholesterol levels were measured at 24-28 weeks gestation. We tested the association between maternal variables and birth weight by univariable analysis. We also used multiple logistic regression analysis to determine whether maternal hyperlipidemia is a risk factor for having an LGA infant.
Results: We enrolled 190 subjects. Among measured maternal lipids, only triglyceride levels correlated with birth weight in univariable analysis (r2= 0.40, P = .000). Logistic regression analysis showed that fasting maternal hypertriglyceridemia was the significant predictor of macrosomia, independent of maternal weight gain and fasting plasma glucose levels. (Odds ratio 11.2; 95% confidence interval 1.5, 31.2; P = .01).
Conclusion: In nondiabetic women, fasting triglyceride levels at midpregnancy correlated positively with newborn weight at term.
Keywords: Birth weight, hypertriglyceridemia, nondiabeic pregnant, normal BMI
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