Impact of Preoperative Rectal Misoprostol on Blood Loss during and after Elective Cesarean Delivery: A Randomized Controlled Trial

  • Sitaula S, Uprety DK, Thakur A, Pradhan T Department of Obstetrics and Gynecology, BPKIHS, Dharan, Sunsari, Nepal.

Abstract

Aims: The aim of this study was to evaluate the effect of preoperative administration of rectal misoprostol onblood loss during and after elective cesarean delivery.


Methods: It was a randomized trial including 200 women, divided into two groups (group A and group B), who were planned for elective cesarean delivery and didn’t have risk of postpartum hemorrhage (PPH). Group A received 400μg misoprostol per-rectal preoperatively and intravenous infusion of oxytocin after delivery as hospital protocol.Group B received only intravenous infusion of oxytocin. Primary outcome measureswere the estimated amount of intraoperative and postoperative (24 hours) blood loss and changes in hemoglobin levels 48 hours after delivery.


Results: Intraoperative and postoperative blood loss in rectal misoprostol and oxytocin group were significantly reduced in comparison to oxytocin only group. Mean blood loss in groupA was 326.9±116.2 mlwhereas; in group B was 397.7±110.1 ml with p value of < 0.001 which was significant.The difference between preoperative and postoperative hemoglobin level after 48 hours was also significant (1.10±0.51 vs 1.35± 0.49 g/dl with p value <0.001).


Conclusions: Preoperative rectal misoprostol was found to be an effective measure to reduce the intraoperative and postoperative blood loss during elective cesarean delivery.


Keywords: cesarean delivery;misoprostol; postpartum hemorrhage.

Published
Jan 30, 2018
How to Cite
PRADHAN T, Sitaula S, Uprety DK, Thakur A,. Impact of Preoperative Rectal Misoprostol on Blood Loss during and after Elective Cesarean Delivery: A Randomized Controlled Trial. Nepal Journal of Obstetrics and Gynaecology, [S.l.], v. 11, n. 02, p. 37-41, jan. 2018. ISSN 1999-8546. Available at: <http://njog.org.np/njog/index.php/njog/article/view/855>. Date accessed: 12 aug. 2020.
Section
Original Articles