Stress in women with Reproductive Failure

  • Sunita Bhandari KIST Medical College, Lalitpur, Nepal

Abstract



Aims: The study aim to measure the level of stress in women with recurrent miscarriage and infertile women undergoing in-vitro fertilization treatment using psychological, endocrinological and immunological markers of stress.


Methods: Group A(Recurrent Miscarriage Group, RM Group) of 20 women who had had at least three or more consecutive spontaneous abortions after negative biomedical diagnostic screening test; Group B (Infertility Group) of 40 infertile women undergoing in-vitro fertilization treatment after down-regulation with Gonadotropin-releasing Hormone (GnRH) agonist in a long protocol and Group C (Control Group) of 15 fertile women were asked to complete the stress questionnaires : the Perceived stress scale (PSS), the Fertility Problem Inventory (FPI), the Positive and Negative Scale (PANAS) and the SF-12 Health Survey. Blood samples were collected to measure natural killer (NK) cells and cortisol levels.


Results: The score of stress questionnaires were significantly high in women with reproductive failure compared to fertile control group (p=0.023 for PSS; p=0.011 for FPI; p=0.013 for negative scale of PANAS) and the score of MCS from SF-12 Health Survey was significantly lower compared to control group (p=0.001). However, no significant differences were seen between women with RM and infertile women undergoing IVF treatment. Women with reproductive failure have increased number of peripheral NK cells compared to controls (p=0.000). No significant difference was found in the serum cortisol level between the women with reproductive failure and fertile women.


Conclusions: Women with reproductive failure perceived higher levels of psychological stress. Level of stress in women with recurrent miscarriage is comparable to that of infertile women undergoing in-vitro fertilization treatment. Increased numbers of NK cells were found in the peripheral blood of women with reproductive failure.


Keywords
infertility, recurrent miscarriage, stress
DOI : http://dx.doi.org/10.3126/njog.v11i1.16268
Published
Jan 22, 2017
How to Cite
BHANDARI, Sunita. Stress in women with Reproductive Failure. Nepal Journal of Obstetrics and Gynaecology, [S.l.], v. 11, n. 1, p. 14-19, jan. 2017. ISSN 1999-8546. Available at: <http://njog.org.np/njog/index.php/njog/article/view/809>. Date accessed: 29 june 2017.
Section
Original Articles