Maternal serum triglyceride at midpregnancy and newborn weight in nondiabetic and normal BMI women

  • Leila Sekhavat, Fatemah Zare, Sedighah Akhavan Karbasi

Abstract

Aim: To determine whether elevated midpregnancy (24 -28 Gestational weeks) maternal serum lipid levels predict the risk of macrosomia in non-diabetic women.

Methods: Nondiabetic pregnant women (who had negative diabetic screens) were enrolled. Fasting serum triglyceride, and total cholesterol levels were measured at 24-28 weeks gestation. We tested the association between maternal variables and birth weight by univariable analysis. We also used multiple logistic regression analysis to determine whether maternal hyperlipidemia is a risk factor for having an LGA infant.

Results: We enrolled 190 subjects. Among measured maternal lipids, only triglyceride levels correlated with birth weight in univariable analysis (r2= 0.40, = .000). Logistic regression analysis showed that fasting maternal hypertriglyceridemia was the significant predictor of macrosomia, independent of maternal weight gain and fasting plasma glucose levels. (Odds ratio 11.2; 95% confidence interval 1.5, 31.2; = .01).

Conclusion: In nondiabetic women, fasting triglyceride levels at midpregnancy correlated positively with newborn weight at term.

Keywords: Birth weight, hypertriglyceridemia, nondiabeic pregnant, normal BMI 

Published
Aug 11, 2015
How to Cite
SEDIGHAH AKHAVAN KARBASI, Leila Sekhavat, Fatemah Zare,. Maternal serum triglyceride at midpregnancy and newborn weight in nondiabetic and normal BMI women. Nepal Journal of Obstetrics and Gynaecology, [S.l.], v. 3, n. 1, p. 19-23, aug. 2015. ISSN 1999-8546. Available at: <http://njog.org.np/njog/index.php/njog/article/view/279>. Date accessed: 24 aug. 2019.
Section
Original Articles